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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
20.91
Human Site:
Y444
Identified Species:
46
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
Y444
G
T
V
K
I
T
D
Y
S
I
S
K
R
L
A
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
Y444
G
T
V
K
I
T
D
Y
S
I
S
K
R
L
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
Y444
G
N
V
K
I
T
D
Y
S
I
S
K
R
L
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
Y443
G
T
V
K
I
T
D
Y
S
I
S
K
R
L
A
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
H404
G
H
V
R
M
T
D
H
S
I
S
K
R
L
A
Chicken
Gallus gallus
XP_421203
1656
188583
Y455
G
N
V
K
V
T
D
Y
S
I
S
K
R
L
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
L365
H
L
S
A
S
C
V
L
L
D
A
R
G
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
I12
D
F
L
L
K
C
L
I
N
D
E
R
K
R
W
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
Y481
G
R
L
R
V
A
N
Y
S
M
C
K
R
L
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
A123
L
S
L
L
E
D
Q
A
N
S
N
A
R
E
G
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
L424
S
T
Y
G
Y
T
V
L
N
M
L
S
R
Y
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
93.3
N.A.
100
N.A.
N.A.
73.3
86.6
N.A.
0
N.A.
N.A.
0
N.A.
40
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
N.A.
N.A.
93.3
93.3
N.A.
13.3
N.A.
N.A.
26.6
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
10
0
10
0
0
10
10
0
0
55
% A
% Cys:
0
0
0
0
0
19
0
0
0
0
10
0
0
0
0
% C
% Asp:
10
0
0
0
0
10
55
0
0
19
0
0
0
10
0
% D
% Glu:
0
0
0
0
10
0
0
0
0
0
10
0
0
10
0
% E
% Phe:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
64
0
0
10
0
0
0
0
0
0
0
0
10
0
10
% G
% His:
10
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
37
0
0
10
0
55
0
0
0
0
0
% I
% Lys:
0
0
0
46
10
0
0
0
0
0
0
64
10
0
0
% K
% Leu:
10
10
28
19
0
0
10
19
10
0
10
0
0
64
0
% L
% Met:
0
0
0
0
10
0
0
0
0
19
0
0
0
0
0
% M
% Asn:
0
19
0
0
0
0
10
0
28
0
10
0
0
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
0
19
0
0
0
0
0
0
0
19
82
10
0
% R
% Ser:
10
10
10
0
10
0
0
0
64
10
55
10
0
0
0
% S
% Thr:
0
37
0
0
0
64
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
55
0
19
0
19
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% W
% Tyr:
0
0
10
0
10
0
0
55
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _